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  • CRISPR nucleic acid rapid detection technology pCIS suitable for PCR equipment

    In 2021, based on the CRISPR detection platform, it was hailed as the "next generation molecular diagnostic technology" by Science magazine in the United States! CRISPR Disrupts Traditional Medicine: Diagnose a disease in just a few minutes on a piece of paper!


    Infection seriously endangers human life and health

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    PCIS - In-hospital solutions for infection

    Service target: Clinical infection patients in nearly 2000 tertiary hospitals across the country, including infectious disease departments, respiratory departments, pediatrics, and ICUs, providing timely and accurate diagnosis and treatment for many patients, saving lives and reducing medical costs.

    Service model: end-to-end business solutions. Each tertiary hospital sells one technology at a time, and the Quebec Medical Laboratory reports on providing in hospital solutions for rapid pathogen testing in critically ill infected patients.

    9/18/27/108 BT-CRISPR Pathogen - Rapid Detection of Pathogens in Critically Infected Patients

    Quick: On 9/18/27/108, pathogens and drug resistance typing of critical and severe bacterial infections were identified, achieving a 30 minute rapid hospital examination

    Sensitivity: Clear clinical significance, high sensitivity, and moderate price,

    Excellent: In terms of clinical emergency monitoring, it is superior to mNGS and tNGS for pan bacterial testing


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    High sensitivity detection of pathogens in critical illness such as pneumonia, sepsis, and meningitis is superior to mNGS and tNGS pan bacterial tests.


    Rapid detection of pathogens in critically infected patients

    1. PCIS: RPA-CRISPR nucleic acid rapid detection technology applicable to all PCR instruments, with a full process of 30 minutes and a single copy of the detection limit.

    2. Exclusive patented PCR reaction sleeve (including reagents), bottom RPA microchip, upper CRISPR microchip. The cover is not opened throughout the entire process, and there is no pollution.

    3. The reaction sleeves of RPA and CRISPR microchips using exclusive freeze-drying technology are stored at room temperature for 1 year.

    4. Only three pieces of nucleic acid extraction equipment, handheld centrifuge, and PCR instrument are required, without liquid configuration, greatly reducing equipment and operator requirements.

    5. The cost of pCIS is low, and medical institutions at or above the county level are equipped with a large number of PCR machines, which have the key application conditions for rapid detection of infectious pathogens.

    6. Original RPA-CRISPR special room temperature micro core sleeve, equipped with conventional PCR instrument for use

    Fast detection speed, high accuracy, and wide coverage


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    Applicable population: hospitalized patients with refractory or critical infections, especially ICU or acute infection patients

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    Technical comparison

    mNGS (Macrogenomics) /tNGS(

    pCIS (RPA-CRISPR nucleic acid rapid test)

    Time

    7天

    30min

    Convenience

    The laboratory needs to be equipped with large-scale sequencing instruments

    Only three pieces of nucleic acid extraction equipment, handheld centrifuge, and PCR instrument are required, without liquid configuration, greatly reducing equipment and operator requirements.

    Cost

    High

    Low

    Pathogen coverage rate

    Covering rare pathogens

    Covering high-frequency pathogens

    Sensitivity

    High

    Higher

    Tumor genetic testing, major infectious disease testing

    Clinical cytomolecular genetics, clinical immunity, serological testing

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